Elizabeth Crawford (voice)

Helen

Betty

Upshur 'Maw' Clampette

Aunt Butch

Harper Pitt

The Grande Dame

Sister Sarah Joan

Marjorie

Miriam

Mrs. Glenn

Margaret Conlon

Self

The Youngest Daughter (later)

Aunt Mel

Mom

Mrs. Portman

Lois Blair

Belle

Abby

Dr. Imberman

Helen Bessolo

Elizabeth

Social Worker

Inge (as an older woman)

Self

Ellie Silverstein

Reverend Anna Howard Shaw

Helen

Helen Rounds

Dr. Iris Hineman

Lucy Thompson

Mother

Helen Jackson

Ginger

Mrs. Ferriter

Luluna

Aunt Meg

Helen's Mother

Sophia

Madge Wallace Gates

Orna

D-Fens' Mother

Lou Wheaton

voice

Lureen

Mrs. Bell

Mama Threadgoode

Alice Todd

Margaret

Ma Joad

(voice)

Brontë's Mother

Self

Mrs. Nelson, Mardukas's Friend

Martha

Sara

Sarah

Mary Neal

Helen Giles

Mrs. Prescott

Mare Spofford

Mrs. Carnahan

Bertha Dorset

Kathy

Cornelia

Mrs. Axman

Anita Cunningham

Elinore

Partita Dupea

Jane Aldridge

Woman (segment "Talk to Me Like the Rain and Let Me Listen")

Evelyn

Hilda

Spurs O'Brien

Anne